Antioxidant Treatment Against Paraquat Toxicity

The production of free radicals is the main mechanism of paraquat poisoning. When produced in excess, these free radicals can cause oxidative stress, a process that can alter cell membranes and result in cell damage down to the DNA level.

This damage ultimately contributes to a handful of life-long conditions, including neurodegenerative disorders, such as Parkinson’s disease, which happens to be associated with paraquat exposure

In fact, farmers and agricultural workers who subsequently developed Parkinson’s disease after chronic exposure to paraquat in the workplace decided to file a paraquat exposure lawsuit against Syngenta AG, the manufacturer of the popular herbicide. 

Plaintiffs claim that they could have avoided a Parkinson’s disease diagnosis if the chemical manufacturer warned them of such health risk by putting a warning on the paraquat label. Today, a large percentage of herbicide-related deaths are linked to paraquat, but there is still no recognized cure for its toxicity. 

One of the current treatment regimens, however, focuses on the use of antioxidants, which protect the body from free radicals and therefore reduce the damaging effects of paraquat to our cells. 

Read on to learn more about how antioxidant strategies can be beneficial for patients with high dose paraquat poisoning. 

What are Antioxidants?

Antioxidants are substances that prevent or limit certain types of cell damage caused by free radicals. Free radicals are highly unstable molecules that have the potential to create cell damage. Molecules are partly made up of electrons, and electrons are typically in even numbers. 

Free radicals, however, have an odd number of electrons – this makes them unstable and highly reactive. And because they are missing an electron, they proceed and steal one from wherever they can – from other stable molecules in your blood to your cells. 

This process is what causes damage to surrounding cells. Antioxidants, on the other hand, are also unstable and have an uneven number of electrons, just like free radicals. But unlike free radicals, they don’t take electrons from other molecules and instead donate some of their own electrons in order to neutralize free radicals. This way, antioxidants keep free radicals in check and prevent their buildup, which can in turn cause oxidative stress, a phenomenon that is linked to aging and various other chronic diseases. 

Role of Antioxidants in Paraquat Toxicity

Role of Antioxidants in Paraquat Toxicity

Clinical management of paraquat ingestion is typically directed towards the use of antioxidants. The different roles that antioxidants play in paraquat toxicity are listed below. 

1. Improves the Patient’s Survival Rate

A 2018 study reported that high-dose long-term antioxidant treatment significantly improved the survival rate of patients with paraquat intoxication. This is especially true in cases where high doses of paraquat were ingested.

2. Reduces Lung Fibrosis in Patients

The main target organ for paraquat toxicity is the lung. As a result, paraquat quickly accumulates in lung cells, leading to the production of free radicals known as reactive oxygen species (ROS), which ultimately results in lung scarring or pulmonary fibrosis. Several studies have shown that antioxidants may protect against paraquat-induced lung fibrosis and experts speculate this may be because of their antioxidant properties. 

3. Enhances Liver Function

Severe paraquat poisoning damages liver function in patients and could lead to multi-organ failure, which is one of the leading causes of death among those who suffered from paraquat intoxication. Various cell and animal experiments have reported that antioxidants can reduce the production of free radicals and as a result protect liver function in patients.

4. Protects Lung Function

The generation of free radicals triggered by paraquat can result in the mass production of inflammatory cytokines in the lung. Inflammatory cytokines have been shown to contribute to lung dysfunction. Fortunately, high-dose long-term antioxidant therapy can effectively reduce the generation of inflammatory cytokines in the lung, enhancing lung function and preventing lung fibrosis in the process. 

5. Protects Against Paraquat-Induced Lung Damage

One of the lasting effects of paraquat poisoning in survivors is lung damage or severe lung fibrosis that permanently affects their pulmonary function even after treatment. The results of an animal study suggest that the antioxidant vitamin E offers protection against paraquat-induced lung damage when delivered directly to the lung 24 hours before paraquat administration. A 2018 study also observed this potential of antioxidants, but suggested that high-dose long-term antioxidant therapy should be applied instead of the conventional antioxidant treatment. 

What Reduces Paraquat Toxicity?

Some treatment options, such as activated charcoal, Fuller’s earth, or antioxidants may reduce paraquat toxicity. Today, because there is no recognized specific antidote for paraquat poisoning, physicians use these treatment regimens instead to fight the toxic effects produced by the life-threatening poison. 

Activated charcoal and Fuller’s earth are often used for the medical management of paraquat ingestion because they help prevent further absorption of the substance into the body. On the other hand, the protective effects of antioxidants against poisoning by paraquat include the reduction of oxidative stress and inflammation as well as the induction of antioxidant defenses. 

How Antioxidants Reduce Toxicity

Antioxidants reduce toxicity by donating an electron to rampaging free radicals to stabilize them, thus reducing its destructive effects and minimizing cellular damage. By delaying or inhibiting cellular damage through free radical scavenging, antioxidants also reduce the risk of suffering from free radical-related health problems.

In the case of the toxic herbicide paraquat, the substance also induces its toxic effects through the same mechanism of destructing cell membranes and causing eventual cell death. This is why innovations in the management of paraquat intoxication have involved the use of antioxidants. 

How do Antioxidants Prevent Oxidative Damage

How do Antioxidants Prevent Oxidative Damage?

Antioxidants prevent oxidative damage by inhibiting the production of free radicals, which, when produced in excess, create oxidative stress and attack the protein, lipid, or DNA components in our system.  Damaged DNA is responsible for a host of long-term health problems and aging-related changes that occur in the body. 

What Are the Ways to Reduce Oxidative Stress?

Because you have no control over the biochemical processes that occur in your body, there is no way to completely avoid oxidative stress. However, there are strategies that can help you minimize its damage to your body.  The ways to reduce oxidative stress are listed below. 

  • Limit your exposure to unnecessary free radicals: Some free radicals occur naturally in the body. However, there are also external sources of free radicals that you can’t always avoid. For instance, in the workplace, you can be exposed to different toxins, air pollution, or toxic chemicals, such as pesticides or herbicides. Practicing safety around these free radical sources and avoiding them to the extent you can may protect you from excess levels of free radicals.

  • Eat an antioxidant-rich diet: Antioxidants aren’t called free radical scavengers for no reason. Antioxidants help you fight these electron-stealing compounds to keep the integrity of your cells. Some examples of foods that are rich in antioxidants include broccoli, almonds, avocado, legumes, leafy greens, carrots, tomatoes, and olives, to name a few. Eating five servings a day of these fruits and vegetables can help your body produce more antioxidants.

  • Make healthy lifestyle choices: Making lifestyle changes can also help prevent or reduce oxidative stress. These include exercising regularly, quitting smoking, limiting consumption of processed foods, decreasing alcohol intake, and getting plenty of sleep. 

Is Antioxidant Therapy Effective Against Paraquat Toxicity?

Yes, antioxidant therapy is effective against paraquat toxicity. Several studies have found that adding antioxidants to the conventional management of paraquat ingestion helped improve patient’s survival rate, prevented lung scarring in the advanced stage, and reduced overall lung function in survivors. 

Although the mechanisms by which antioxidants stop oxidative stress from occurring is still poorly understood, experts speculate that this ability may be attributed to their antioxidant properties in inhibiting the production of reactive oxygen species (ROS) caused by paraquat. As a result, the destructive effects of ROS to cells are avoided and there are better chances of paraquat poisoning being treated. 

However, researchers and scientists admit that more work needs to be done to create an antidote for paraquat poisoning. Further well-designed studies are also needed to evaluate the outcome of different presently recommended treatment protocols for paraquat intoxication.

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